Nature Communications (Apr 2022)
Microvascular stabilization via blood-brain barrier regulation prevents seizure activity
- Chris Greene,
- Nicole Hanley,
- Cristina R. Reschke,
- Avril Reddy,
- Maarja A. Mäe,
- Ruairi Connolly,
- Claire Behan,
- Eoin O’Keeffe,
- Isobel Bolger,
- Natalie Hudson,
- Conor Delaney,
- Michael A. Farrell,
- Donncha F. O’Brien,
- Jane Cryan,
- Francesca M. Brett,
- Alan Beausang,
- Christer Betsholtz,
- David C. Henshall,
- Colin P. Doherty,
- Matthew Campbell
Affiliations
- Chris Greene
- Smurfit Institute of Genetics, Trinity College Dublin
- Nicole Hanley
- Smurfit Institute of Genetics, Trinity College Dublin
- Cristina R. Reschke
- FutureNeuro, Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences
- Avril Reddy
- Smurfit Institute of Genetics, Trinity College Dublin
- Maarja A. Mäe
- Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University
- Ruairi Connolly
- FutureNeuro, Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences
- Claire Behan
- FutureNeuro, Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences
- Eoin O’Keeffe
- Smurfit Institute of Genetics, Trinity College Dublin
- Isobel Bolger
- Smurfit Institute of Genetics, Trinity College Dublin
- Natalie Hudson
- Smurfit Institute of Genetics, Trinity College Dublin
- Conor Delaney
- Smurfit Institute of Genetics, Trinity College Dublin
- Michael A. Farrell
- Department of Neuropathology, Beaumont Hospital
- Donncha F. O’Brien
- Department of Neurosurgery, Beaumont Hospital
- Jane Cryan
- Department of Neuropathology, Beaumont Hospital
- Francesca M. Brett
- Department of Neuropathology, Beaumont Hospital
- Alan Beausang
- Department of Neuropathology, Beaumont Hospital
- Christer Betsholtz
- Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University
- David C. Henshall
- FutureNeuro, Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences
- Colin P. Doherty
- FutureNeuro, Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences
- Matthew Campbell
- Smurfit Institute of Genetics, Trinity College Dublin
- DOI
- https://doi.org/10.1038/s41467-022-29657-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
The mechanisms underlying epilepsy development are not well understood. Here the authors show that loss of a key component of the so called blood-brain barrier drives seizures in mice and is also lost in humans with treatment resistant epilepsy
