Nature Communications (Oct 2022)

Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability

  • Michael B. Heskett,
  • Athanasios E. Vouzas,
  • Leslie G. Smith,
  • Phillip A. Yates,
  • Christopher Boniface,
  • Eric E. Bouhassira,
  • Paul T. Spellman,
  • David M. Gilbert,
  • Mathew J. Thayer

DOI
https://doi.org/10.1038/s41467-022-34099-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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Heskett et al. describe several members of a class of long non-coding RNAs, known as ASARs, which show distinct epigenetic regulation between subclonal lineages and are essential for normal DNA replication timing and stability of human autosomes.