Mitigating Paxlovid™-induced drug‒drug interaction toxicity: an in silico insight

Abstract

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The clinical drug-drug interaction side-effects of Ritonavir, an ingredient in Paxlovid™, have been documented, highlighting the need to explore alternative administration methods for Nirmatrelvir, another drug in the Paxlovid™ combination. In this study, the skin permeability potential of Nirmatrelvir was assessed using various in silico models. The prediction results suggest that Nirmatrelvir could be administrated via the transdermal route, offering a promising avenue to enhance the efficacy of anti-COVID-19 agents.

Keywords

• in silico
• skin permeability
• Paxlovid
• nirmatrelvir
• COVID-19