Clofazimine: History and Perspectives

Abstract

The review analyses 47 publications that follow the pathway of clofazimine from its discovery to recognition as a Group B drug for treatment of multiple drug resistant tuberculosis. It describes its mechanism of action and effects on Mycobacterium tuberculosis, pharmacokinetics, and safety parameters.

Keywords

• клофазимин
• микобактерии туберкулеза
• механизм действия
• множественная лекарственная устойчивость
• химиотерапия
• нежелательные явления