EFFECTS OF INSULIN-LIKE GROWTH FACTOR TYPE I ON BONE REMODELING IN PHYSIOLOGICAL PREGNANCY AND NORMAL LEVELS OF VITAMIN D

Abstract

During pregnancy the levels of IGF-I increase and in III trimester exceed greatly the values of I trimester. Its significant increase is noted from 22-24 weeks of pregnancy. Correlation analysis revealed a moderate negative correlation between the level of IGF-I in II trimester and distal forearm BMD (r = -0,35, p<0,5). Also a moderate positive correlation between the level of IGF-I and a marker of bone synthesis osteocalcin in the II and III trimesters of pregnancy was revealed (r = 0,46, p <0,05 and r = 0,41, p<0,05, respectively). Conclusions: IGF-I effects bone remodeling of long bones during pregnancy. It is probable that under the influence of IGF-I synthesis of bone matrix is increased, which in the presence of low calcium intake may be associated with reduced BMD at these bone sites.

Keywords

• беременность
• остеопения
• ремоделирование костной ткани
• витамин D
• ИФР-1
• паратиреоидный гормон