Frontiers in Public Health (Jan 2024)

Progress in the study of aging marker criteria in human populations

  • Yan He,
  • Yan He,
  • Zhe Li,
  • Yue Niu,
  • Yuting Duan,
  • Qian Wang,
  • Xiaomin Liu,
  • Zheyi Dong,
  • Ying Zheng,
  • Yizhi Chen,
  • Yizhi Chen,
  • Yong Wang,
  • Delong Zhao,
  • Xuefeng Sun,
  • Guangyan Cai,
  • Zhe Feng,
  • Weiguang Zhang,
  • Xiangmei Chen,
  • Xiangmei Chen

DOI
https://doi.org/10.3389/fpubh.2024.1305303
Journal volume & issue
Vol. 12

Abstract

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The use of human aging markers, which are physiological, biochemical and molecular indicators of structural or functional degeneration associated with aging, is the fundamental basis of individualized aging assessments. Identifying methods for selecting markers has become a primary and vital aspect of aging research. However, there is no clear consensus or uniform principle on the criteria for screening aging markers. Therefore, we combine previous research from our center and summarize the criteria for screening aging markers in previous population studies, which are discussed in three aspects: functional perspective, operational implementation perspective and methodological perspective. Finally, an evaluation framework has been established, and the criteria are categorized into three levels based on their importance, which can help assess the extent to which a candidate biomarker may be feasible, valid, and useful for a specific use context.

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