Communications Biology (Jan 2021)

The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer

  • Sofia Lage-Vickers,
  • Juan Bizzotto,
  • Maria Pia Valacco,
  • Pablo Sanchis,
  • Sergio Nemirovsky,
  • Estefania Labanca,
  • Carlos Scorticati,
  • Osvaldo Mazza,
  • Antonina Mitrofanova,
  • Nora Navone,
  • Elba Vazquez,
  • Javier Cotignola,
  • Geraldine Gueron

DOI
https://doi.org/10.1038/s42003-020-01645-2
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

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Using integrative tissue-omics, Lage-Vickers, Bizzotto et al. classify prostate cancer patients into high YWHAZ and NDRG1 expression subgroups that correlate with a high and intermediate risk of disease progression. This study identifies molecular biomarkers associated with aggressive prostate cancer.