Nature Communications (Nov 2018)
Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
- Naveed Ishaque,
- Mohammed L. Abba,
- Christine Hauser,
- Nitin Patil,
- Nagarajan Paramasivam,
- Daniel Huebschmann,
- Jörg Hendrik Leupold,
- Gnana Prakash Balasubramanian,
- Kortine Kleinheinz,
- Umut H. Toprak,
- Barbara Hutter,
- Axel Benner,
- Anna Shavinskaya,
- Chan Zhou,
- Zuguang Gu,
- Jules Kerssemakers,
- Alexander Marx,
- Marcin Moniuszko,
- Miroslaw Kozlowski,
- Joanna Reszec,
- Jacek Niklinski,
- Jürgen Eils,
- Matthias Schlesner,
- Roland Eils,
- Benedikt Brors,
- Heike Allgayer
Affiliations
- Naveed Ishaque
- Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580
- Mohammed L. Abba
- Department of Experimental Surgery-Cancer Metastasis, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg
- Christine Hauser
- Department of Experimental Surgery-Cancer Metastasis, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg
- Nitin Patil
- Department of Experimental Surgery-Cancer Metastasis, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg
- Nagarajan Paramasivam
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Daniel Huebschmann
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Jörg Hendrik Leupold
- Department of Experimental Surgery-Cancer Metastasis, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg
- Gnana Prakash Balasubramanian
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)
- Kortine Kleinheinz
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Umut H. Toprak
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Barbara Hutter
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)
- Axel Benner
- Department of Biostatistics, German Cancer Research Centre (DKFZ)
- Anna Shavinskaya
- Department of Experimental Surgery-Cancer Metastasis, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg
- Chan Zhou
- Department of Experimental Surgery-Cancer Metastasis, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg
- Zuguang Gu
- Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580
- Jules Kerssemakers
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Alexander Marx
- Institute of Pathology, University Hospital Mannheim (UMM)
- Marcin Moniuszko
- Faculty of Medicine, Medical University of Bialystok
- Miroslaw Kozlowski
- Faculty of Medicine, Medical University of Bialystok
- Joanna Reszec
- Faculty of Medicine, Medical University of Bialystok
- Jacek Niklinski
- Faculty of Medicine, Medical University of Bialystok
- Jürgen Eils
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Matthias Schlesner
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Roland Eils
- Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580
- Benedikt Brors
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)
- Heike Allgayer
- Department of Experimental Surgery-Cancer Metastasis, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg
- DOI
- https://doi.org/10.1038/s41467-018-07041-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
The evolution and genetic nature of metastatic lesions is not completely characterized. Here the authors perform a comprehensive whole-genome study of colorectal metastases in comparison to matched primary tumors and define a multistage progression model and metastasis-specific changes that, in part, are therapeutically actionable.
