Diabetes, Metabolic Syndrome and Obesity (Apr 2023)

Risk Factors Associated with Bone Marrow Adiposity Deposition in Postmenopausal Women in the CASH China Study

  • Xu L,
  • Gong Y,
  • Zhao Q,
  • Blake GM,
  • Li K,
  • Zhang Y,
  • Liu Q,
  • Li C,
  • Cheng X

Journal volume & issue
Vol. Volume 16
pp. 1167 – 1176

Abstract

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Li Xu,1,* Yanping Gong,2,* Qian Zhao,3 Glen M Blake,4 Kai Li,1 Yong Zhang,1 Qianqian Liu,2 Chunlin Li,2 Xiaoguang Cheng1 1Department of Radiology, Beijing Jishuitan Hospital, Beijing, People’s Republic of China; 2Department of Endocrinology, the Second Medical Center, the Chinese People’s Liberation Army General Hospital, National Clinical Research Center for Geriatric Disease, Beijing, 100853, People’s Republic of China; 3International Medical Center, Sichuan University West China Hospital, Chengdu, People’s Republic of China; 4Biomedical Engineering Department, King’s College London, London, UK*These authors contributed equally to this workCorrespondence: Xiaoguang Cheng, Department of Radiology, Beijing Jishuitan Hospital, Beijing, 100035, People’s Republic of China, Email [email protected] Chunlin Li, Department of Endocrinology, the Second Medical Center, the Chinese People’s Liberation Army General Hospital, National Clinical Research Center for Geriatric Disease, Beijing, 100853, People’s Republic of China, Email [email protected]: To investigated the factors that influence BMAC.Patients and Methods: Quantitative computed tomography (QCT) and magnetic resonance imaging (MRI) were applied to measure abdominal fat areas, liver fat content, erector muscle fat content, and BMAC of the L2-4 vertebrae. Sex hormone, adipokine, and inflammatory factor levels were measured on the same day.Results: Although age, erector muscle fat content, estradiol, testosterone, and adiponectin/leptin levels showed correlations with BMAC in the correlation analysis, the equations obtained from the whole population by multivariate analysis were unclear. Patients were stratified according to BMAC quartiles, and differences were found in vBMD, age, estradiol, testosterone, and erector muscle fat content among the four quartiles. Logistic analyses confirmed that age, estradiol/testosterone ratio, and TNF-α had independent effects on BMAC in all quartiles. In addition, height was related to higher BMAC quartiles, and glucose was related to lower BMAC quartiles.Conclusion: Compared to other body fats, BMAC is a unique fat depot. Age, estradiol/testosterone ratio, and TNF-α are all key influencing factors related to BMAC in postmenopausal women. Furthermore, height and glucose levels were related to BMAC in the higher and lower BMAC quartiles, respectively.Keywords: bone marrow adiposity, postmenopausal women, age, adipokines, sex hormones

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