Український стоматологічний альманах (Mar 2018)
THE CHANGES IN TOTAL PROTEIN LEVEL IN BLOOD SERUM AND ORAL FLUID OF THE PATIENTS DURING THE TREATMENT OF GENERALIZED PERIODONTITIS COMBINED WITH CHRONIC LIVER DISEASES
Abstract
Introduction. Clinical medicine has numerous evidences for mutual complications of different diseases of internal organs associated with generalized periodontitis (GP). It is known that in patients with GP all kinds of metabolism are disturbed. It is not fully clarified how these changes occur during the combined pathology of periodontal and hepatobiliary system, and there are no elaborated methods of complex treatment of patients in such cases. Therefore, research in this direction remains actual. Aim. The study of total protein (TP) content in blood serum and oral fluid of the patients with GP with and without concomitant liver pathology and its changes under the influence of complex treatment. Methods. 24 healthy and 110 patients with chronic GP of I degree were examined, among them: 34 – without liver pathology, 49 – with concomitant cryptogenic hepatitis (CH) and 27 – with concomitant subcompensated liver cirrhosis (SLC). The level of TP in blood serum and oral fluid was determined. There were selected 19 patients with GP without concomitant pathology and 29 patients with GP combined with CH. It included initial periodontal therapy, local treatment using Stomatofit liquid, mixture of Glutargin and Atoxil and general therapy using medications Glutargin and Calcemin. Results. In patients with GP without and with concomitant CH and SLC the level of TP in blood serum significantly reduced (on 4,39%, 11,12% and 15,07%), and in oral fluid – increased (in 1,48, 2,70, і 3,47 times). After the treatment the content of TP in blood serum increased in the case of GP, achieving the data of healthy people, and with GP on the background of CH – on 7,73% (р10,05) and 1,85% (р10,05) and reliable decreasing - in the case of GP combined with CH (р1<0,001).
