How to switch a master switch

Christopher Hein; Alfred Wittinghofer; Volker Dötsch

doi:10.7554/elife.01159

eLife (Jul 2013)

How to switch a master switch

Christopher Hein,
Alfred Wittinghofer,
Volker Dötsch

Affiliations

Christopher Hein: Institute of Biophysical Chemistry and the Buchmann Institute of Molecular Life Sciences, Goethe University, Frankfurt, Germany
Alfred Wittinghofer: Max Planck Institute of Molecular Physiology, Dortmund, Germany
Volker Dötsch: Institute of Biophysical Chemistry and the Buchmann Institute of Molecular Life Sciences, Goethe University, Frankfurt, Germany

DOI: https://doi.org/10.7554/elife.01159
Journal volume & issue: Vol. 2

Abstract

Read online

The crystal structure of a nucleotide exchange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like behaviour of the signalling protein Ras.

Published in eLife

ISSN: 2050-084X (Online)
Publisher: eLife Sciences Publications Ltd
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Biology (General)
Website: https://elifesciences.org

About the journal

Abstract

Keywords