BMC Veterinary Research (Nov 2019)

Lipid and metabolic profiles in female dogs with mammary carcinoma receiving dietary fish oil supplementation

  • Keidylania Costa-Santos,
  • Karine Damasceno,
  • Ricardo Dias Portela,
  • Ferlando Lima Santos,
  • Genira Carneiro Araújo,
  • Emanoel Ferreira Martins-Filho,
  • Laís Pereira Silva,
  • Thiago Doria Barral,
  • Stefanie Alvarenga Santos,
  • Alessandra Estrela-Lima

DOI
https://doi.org/10.1186/s12917-019-2151-y
Journal volume & issue
Vol. 15, no. 1
pp. 1 – 13

Abstract

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Abstract Background Dyslipidemias induce angiogenesis and accelerate the development and in vitro growth of breast tumors. The aim of this study was to assess the lipid and metabolic profile of female dogs with mammary carcinomas and their correlations with body condition score and degree of tumor malignancy, as well as to study the effect of dietary fish oil supplementation on these animals. Results Overweight or obese dogs had more aggressive carcinomas and higher triglyceride (p = 0.0363), VLDL (p = 0.0181), albumin (p = 0.0188), globulin (p = 0.0145) and lactate (p = 0.0255) concentrations. There was no change in the lipid profile after supplementation with fish oil at any concentration. However, in relation to the metabolic profile, glucose (p = 0.0067), total protein (p = 0.0002) and globulin (p = 0.0002) concentrations were increased when 90% omega-3 fish oil was used as a dietary supplement. Conclusion Obese dogs showed altered lipid and metabolic profiles and more aggressive tumors, suggesting an important relationship between dyslipidemia and tumor aggressiveness. Supplementation with fish oil, rich in omega-3 fatty acids, may alter metabolic parameters in cancer patients.

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