Nature Communications (Jun 2022)
Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders
- Xinyuan Zhang,
- Anastasia M. Lucas,
- Yogasudha Veturi,
- Theodore G. Drivas,
- William P. Bone,
- Anurag Verma,
- Wendy K. Chung,
- David Crosslin,
- Joshua C. Denny,
- Scott Hebbring,
- Gail P. Jarvik,
- Iftikhar Kullo,
- Eric B. Larson,
- Laura J. Rasmussen-Torvik,
- Daniel J. Schaid,
- Jordan W. Smoller,
- Ian B. Stanaway,
- Wei-Qi Wei,
- Chunhua Weng,
- Marylyn D. Ritchie
Affiliations
- Xinyuan Zhang
- Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania
- Anastasia M. Lucas
- Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania
- Yogasudha Veturi
- Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania
- Theodore G. Drivas
- Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania
- William P. Bone
- Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania
- Anurag Verma
- Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania
- Wendy K. Chung
- Department of Pediatrics and Medicine, Columbia University
- David Crosslin
- Department of Biomedical Informatics and Medical Education, University of Washington
- Joshua C. Denny
- Department of Medicine, Vanderbilt University
- Scott Hebbring
- Center for Human Genetics, Marshfield Clinic
- Gail P. Jarvik
- Department of Biomedical Informatics and Medical Education, University of Washington
- Iftikhar Kullo
- Division of Cardiovascular Diseases, Mayo Clinic
- Eric B. Larson
- Kaiser Permanente Washington Health Research Institute
- Laura J. Rasmussen-Torvik
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Daniel J. Schaid
- Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic
- Jordan W. Smoller
- Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital
- Ian B. Stanaway
- Department of Biomedical Informatics and Medical Education, University of Washington
- Wei-Qi Wei
- Department of Biomedical Informatics, Vanderbilt University
- Chunhua Weng
- Department of Biomedical Informatics, Columbia University
- Marylyn D. Ritchie
- Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania
- DOI
- https://doi.org/10.1038/s41467-022-30678-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Circulatory system diseases and nervous system disorders often co-occur in patients. Here the authors use eMERGE and UK BioBank data to identify genomic regions associated with both phenotypes, providing insight into the relationship between these conditions.
