Data on the drug release profiles and powder characteristics of the ethyl cellulose based microparticles prepared by the ultra-fine particle processing system
Tingting Peng,
Yin Shi,
Chune Zhu,
Disang Feng,
Xiangyu Ma,
Peipei Yang,
Xuequn Bai,
Xin Pan,
Chuan-yu Wu,
Wen Tan,
Chuanbin Wu
Affiliations
Tingting Peng
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China
Yin Shi
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China
Chune Zhu
Institute for Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China; Corresponding author.Institute for Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China.
Disang Feng
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China
Xiangyu Ma
College of Pharmacy, University of Texas at Austin, Austin, 78712, USA
Peipei Yang
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China
Xuequn Bai
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China
Xin Pan
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China
Chuan-yu Wu
Department of Chemical and Process Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom
Wen Tan
Institute for Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China
Chuanbin Wu
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China; Corresponding author.School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Ethyl cellulose (EC) based microparticles (MPs) could provide sustained release for Huperzine A. The drug release mechanism of MPs was exploited to achieve an ideal drug release profile. We previously found that the wettability of MPs greatly contributed to facilitating drug release, which was detailed in a research article entitled “Huperzine A loaded multiparticulate disintegrating tablet: Drug release mechanism of ethyl cellulose microparticles and pharmacokinetic study” (Peng et al., 2019) [1]. In this article, the influence of different polymers and drugs on the drug release behavior was investigated to broaden or compensate this finding. Besides, powder characterization of MPs was used to evaluate the further application of MPs for tablets. Keywords: Microparticles, Drug release profile, Powder characteristic
