Lamina-specific immunohistochemical signatures in the olfactory bulb of healthy, Alzheimer’s and Parkinson’s disease patients

Helen C. Murray; Kory Johnson; Andrea Sedlock; Blake Highet; Birger Victor Dieriks; Praju Vikas Anekal; Richard L. M. Faull; Maurice A. Curtis; Alan Koretsky; Dragan Maric

doi:10.1038/s42003-022-03032-5

Communications Biology (Jan 2022)

Lamina-specific immunohistochemical signatures in the olfactory bulb of healthy, Alzheimer’s and Parkinson’s disease patients

Helen C. Murray,
Kory Johnson,
Andrea Sedlock,
Blake Highet,
Birger Victor Dieriks,
Praju Vikas Anekal,
Richard L. M. Faull,
Maurice A. Curtis,
Alan Koretsky,
Dragan Maric

Affiliations

Helen C. Murray: Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag
Kory Johnson: Bioinformatics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Andrea Sedlock: Flow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Blake Highet: Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag
Birger Victor Dieriks: Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag
Praju Vikas Anekal: Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag
Richard L. M. Faull: Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag
Maurice A. Curtis: Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag
Alan Koretsky: Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Dragan Maric: Flow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health

DOI: https://doi.org/10.1038/s42003-022-03032-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

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Murray et al. present a multiplexed fluorescence-based immunohistochemistry approach and use it to screen up to 100 protein markers in the human olfactory bulb from neurologically healthy, Alzheimer’s, and Parkinson’s disease patients. In doing so, they identify differentially expressed biomarkers in Alzheimer’s, and Parkinson’s disease.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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