Expression of NF⁃κB in oral squamous cell carcinoma and paracancerous tissues and its significance

Abstract

Objective To investigate the expression and significance of NF⁃κB in oral squamous cell carcinoma and paracancerous tissues. Methods Cancerous and paracancerous tissues about 5 mm outside the tumor boundary were cut from 47 patients with OSCC. NF⁃κB expression in these tissues were detected by the immunohistochemical SP meth⁃ od and compared with that in 32 normal oral mucosa tissues. Results The average optical density (OD value) of immu⁃ nohistochemical⁃positive cells in cancer tissues and paracancerous tissues was higher than that in normal tissues, and the difference was statistically significant (P < 0.001). There was no significant difference in the OD values between can⁃ cer tissues and paracancerous tissues (P＝0.356). The rate of NF⁃κB positive expression in cancer tissue and paracancer⁃ ous tissue was significantly higher than that in normal mucosa tissue, and the difference was statistically significant (P < 0.001). There was no significant difference in the rate of NF⁃κB positive expression between cancer tissues and paracan⁃ cerous tissues (P＝0.117), but the rate of moderate⁃to⁃strong positive expression in cancer tissues was significantly high⁃ er than that in paracancerous tissues (P < 0.001). Conclusion NF⁃κB may be involved in the development of OSCC.

Keywords

• Oral neoplasms，
• Carcinoma，
• squamous cell，
• paracancerous tissues，
• NF⁃κB，