Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis

Wenguang Liu; Min Wang; Wei Cheng; Wen Niu; Mi Chen; Meng Luo; Chenxi Xie; Tongtong Leng; Long Zhang; Bo Lei

Bioactive Materials (Mar 2021)

Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis

Wenguang Liu,
Min Wang,
Wei Cheng,
Wen Niu,
Mi Chen,
Meng Luo,
Chenxi Xie,
Tongtong Leng,
Long Zhang,
Bo Lei

Affiliations

Wenguang Liu: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China
Min Wang: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China
Wei Cheng: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China
Wen Niu: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China
Mi Chen: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China
Meng Luo: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China
Chenxi Xie: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China
Tongtong Leng: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China
Long Zhang: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China
Bo Lei: Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710000, China; National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710000, China; Instrument Analysis Center, Xi'an Jiaotong University, Xi'an, 710054, China; Corresponding author. Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, PR China.

Journal volume & issue: Vol. 6, no. 3
pp. 721 – 728

Abstract

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The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge. The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and result in the scar formation. Herein, we reported an anti-inflammatory polycitrate-polyethyleneimine-Ibuprofen (PCEI) and multifunctional PCEI-based F127-ε-polypeptide-alginic (FEA) dressing (FEA-PCEI) for accelerating wound healing and hair follicle neogenesis. PCEI showed the excellent anti-inflammation function through stimulating macrophage towards anti-inflammatory M2 subtype polarization. The FEA-PCEI dressing showed the temperature-response gelation, injectability, robust antibacterial activity, light-damage-resistant, homeostasis ability, and good cytocompatibility. The optimized dosage of FEA-PCEI dressing could significantly accelerate wound healing with anti-infection ability, reduce the scar formation, and promote the hair follicle neogenesis. This study provided a wound-repairing strategy through regulating the phenotype of immune cells by the designing bioactive multifunctional biomaterials.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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