Лечение первичного гипотиреоза: нерешенные вопросы

Abstract

Primary hypothyroidism is one of the most common endocrine disorders. According to modern concepts, replacement monotherapy with levothyroxine (L-T4) is the treatment of choice in primary hypothyroidism. In most cases, compensation of hypothyroidism leads to relief of symptoms and, as a consequence, improvement the quality of life. However, according to different authors, 5—10% of patients with hypothyroidism receiving adequate replacement therapy with L-T4 have persistent symptoms of hypothyroidism, increased levels of anxiety and depression. The review discusses approaches to managing of such patients, and as one of the options — transfer to combination therapy with levothyroxine and triiodothyronine (L-T4+T3).

Keywords

• primary hypothyroidism
• replacement therapy
• autoimmune thyroiditis
• graves'disease
• levothyroxine
• triiodothyronine