Neuropsychiatric Disease and Treatment (Feb 2024)

Does Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder?

  • Jiao Q,
  • Dong Y,
  • Ma X,
  • Ji SS,
  • Liu X,
  • Zhang J,
  • Sun X,
  • Li D,
  • Luo X,
  • Zhang Y

Journal volume & issue
Vol. Volume 20
pp. 353 – 361

Abstract

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Qingyan Jiao,1,* Yeqing Dong,2,* Xiaojuan Ma,3 Shiyi Suzy Ji,4 Xinyu Liu,1 Jian Zhang,1 Xia Sun,1 Dazhi Li,1 Xingguang Luo,5 Yong Zhang1 1Unit of Bipolar Disorder, Tianjin Anding Hospital, Tianjin, 300222, People’s Republic of China; 2Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, 300222, People’s Republic of China; 3Tianjin Medical College, Tianjin, 300222, People’s Republic of China; 4Teachers College, Columbia University, New York, NY, USA; 5Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06511, USA*These authors contributed equally to this workCorrespondence: Yong Zhang, Unit of Bipolar Disorder, Tianjin Anding Hospital, 13 Liulin Road, Hexi District, Tianjin, 300222, People’s Republic of China, Tel/Fax +86 22 8818 8258, Email [email protected]: Major depressive disorder (MDD) is associated with worse cognitive functioning. We aim to examine the association between baseline cognitive functioning and the reduction rate in HDRS-17 total scores and to highlight the predictors of the reduction rate in HDRS-17 total scores in MDD with first-episode, drug-naïve (FED) patients.Patients and Methods: Ninety FED patients were recruited consecutively and evaluated using the 17-item Hamilton Depression Rating Scale (HDRS-17), the 14-item Hamilton Anxiety Scale (HAMA-14), the Functioning Assessment Short Test (FAST) and the MATRICS Consensus Cognitive Battery (MCCB) at baseline and again at week 8.Results: Eighty-four FED patients completed the study. Comparison showed that response group had significantly higher T scores in TMT-A, BACS-SC, WMS-III, BVMT-R, MSCEI and CPT-IP, but showed significantly lower scores in FAST total scores including autonomy, occupational functioning, cognitive functioning, interpersonal relationship than non- response group (all p’s< 0.05). Partial correlation analysis also found that the reduction rate in HDRS-17 total scores could be negatively associated with autonomy, cognitive functioning and interpersonal relationship domains as well as total FAST scores, also was further positively associated with T-scores of BACS-SC, CPT-IP and MSCEI in MCCB, even when accounting for potential confounders. Furthermore, the levels of cognitive function domain, autonomy domain in FAST, and BACS-SC, CPT-IP in MCCB may predict the reduction rate in HDRS-17 total scores in FED patients (all p’s< 0.05).Conclusion: Our findings underscore significant correlations between baseline functioning and the reduction rate in HDRS-17 total scores in FED patients. Moreover, better baseline cognitive function, autonomy, speed of processing and attention/vigilance are more likely to predict patients’ response to antidepressant treatment, indicating pre-treatment better cognitive functioning may be predictors to treatment response in FED.Keywords: FED, FAST, MCCB, treatment response, the reduction rate in HDRS-17 total scores

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