Evaluating the excretory function of solitary kidney in patients with urolithiasis on a background of type 2 diabetes mellitus

Abstract

Background. The purpose was to study intrarenal hemodynamics and excretory function using dynamic renoscintigraphy in patients with urolithiasis of solitary kidney on a background of type 2 diabetes mellitus (DM). Materials and methods. The article presents the data of examination of 62 patients with acquired solitary kidney, who were divided into 3 groups: group 1 — 21 persons with nephrolithiasis of solitary kidney and concomitant type 2 DM; group 2 — 23 patients with nephrolithiasis of solitary kidney; group 3 was presented by 18 patients with “healthy” solitary kidney, which remained after nephrectomy. Biochemical blood tests and dynamic renoscintigraphy were performed. Results. In patients with solitary kidney in case of nephrolithiasis, renal venous hypertension is diagnosed, intraglomerular pressure increases and hyperfiltration and hypersecretion occur. In the presence of DM and its complications, peripheral vascular resistance in the kidney gradually increases with the decline of excretory function. Conclusions. Under conditional compensation of kidney function according to the biochemical blood indexes, in patients with nephrolithiasis of solitary kidney, during dynamic renoscintigraphy the significant negative changes are determined in the intrarenal blood flow and excretory kidney function, especially in patients with type 2 DM.

Keywords

• solitary kidney
• nephrolithiasis
• renoscintigraphy
• type 2 diabetes mellitus
• functional state of the kidney
• glome­rular filtration