BIOCHEMICAL ASPECTS OF PATHOGENESIS AND PREDICTORS OF DEVELOPMENT SEVERE FORMS OF ERYSIPELAS WITH LOCALIZATION ON THE LOWER EXTREMITIES

Abstract

Purpose: to clarify the biochemical mechanisms of their development and the possible predictors of the formation of hemorrhagic component.Materials and methods. For this purpose the parameters of proteolytic (total trypsin-like activity of plasma and plasmin) and anti-proteolytic (A2-macroglobulin and A1-antitripsin) activity of plasma were investigated by biochemical methods in patients with different forms of RLE.Results. The study revealed the significant elevation of the overall trypsin-like activity of blood plasma at the early stages of the disease in patients with more severe disease. Activation of plasmin and reduced activity of A2-macroglobulin make a significant contribution to the formation of this parameter. This was most evident in the subsequent development of hemorrhagic forms of the disease.Summary. These changes reflect the biochemical aspects of the pathogenesis of the disease, can serve as predictors of severe hemorrhagic forms and basis for optimization of therapy at an earlier stage of the disease.

Keywords

• proteolysis fibrinolysis
• prediction