Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23

Abstract

The function of autophagy and how this affects non-alcoholic fatty liver disease is not fully known. Here the authors show that in mice with a targeted disruption of the autophagy pathway in CD11c+ cells, development of NAFLD is accelerated involving IL-23 and blocking of IL-23 reduces disease.