Coding variants of the interleukin-11 receptor with reduced protein maturation show protease-dependent trans-signaling and transduce normal STAT3 signaling

• Birte Kespohl,
• Roland Hartig,
• Yvonne Garbers,
• Juliane Lokau,
• Christoph Garbers

Affiliations

Birte Kespohl

Department of Pathology, Otto-von-Guericke-University, Medical Faculty, 39120 Magdeburg, Germany; Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, 39120 Magdeburg, Germany; Center for Health and Medical Prevention (ChaMP), Otto-von-Guericke-University, 39120 Magdeburg, Germany

Roland Hartig

Institute for Molecular and Clinical Immunology and Service Unit Multiparametric Bioimaging and Cytometry, Medical Faculty, University of Magdeburg, 39120 Magdeburg, Germany

Yvonne Garbers

Institute of Communication Management, Faculty of Management, Culture and Technology (Lingen Campus), Osnabrück University of Applied Sciences, 49809 Lingen, Germany

Juliane Lokau

Department of Pathology, Otto-von-Guericke-University, Medical Faculty, 39120 Magdeburg, Germany; Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, 39120 Magdeburg, Germany; Center for Health and Medical Prevention (ChaMP), Otto-von-Guericke-University, 39120 Magdeburg, Germany

Christoph Garbers

Department of Pathology, Otto-von-Guericke-University, Medical Faculty, 39120 Magdeburg, Germany; Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, 39120 Magdeburg, Germany; Center for Health and Medical Prevention (ChaMP), Otto-von-Guericke-University, 39120 Magdeburg, Germany; Corresponding author. Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, 39120 Magdeburg, Germany. Fax: +49 391 67 15818.