Valproate-Induced Metabolic Syndrome

Natalia A. Shnayder; Violetta V. Grechkina; Vera V. Trefilova; Ilya S. Efremov; Evgenia A. Dontceva; Ekaterina A. Narodova; Marina M. Petrova; Irina A. Soloveva; Liia E. Tepnadze; Polina A. Reznichenko; Mustafa Al-Zamil; Gulnara I. Altynbekova; Anna I. Strelnik; Regina F. Nasyrova

doi:10.3390/biomedicines11051499

Biomedicines (May 2023)

Valproate-Induced Metabolic Syndrome

Natalia A. Shnayder,
Violetta V. Grechkina,
Vera V. Trefilova,
Ilya S. Efremov,
Evgenia A. Dontceva,
Ekaterina A. Narodova,
Marina M. Petrova,
Irina A. Soloveva,
Liia E. Tepnadze,
Polina A. Reznichenko,
Mustafa Al-Zamil,
Gulnara I. Altynbekova,
Anna I. Strelnik,
Regina F. Nasyrova

Affiliations

Natalia A. Shnayder: Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia
Violetta V. Grechkina: Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia
Vera V. Trefilova: Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia
Ilya S. Efremov: Department of Psychiatry and Narcology, Bashkir State Medical University, 450008 Ufa, Russia
Evgenia A. Dontceva: Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
Ekaterina A. Narodova: Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
Marina M. Petrova: Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
Irina A. Soloveva: Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
Liia E. Tepnadze: Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
Polina A. Reznichenko: Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
Mustafa Al-Zamil: Department of Physiotherapy, Faculty of Continuing Medical Education, Peoples’ Friendship University of Russia, 117198 Moscow, Russia
Gulnara I. Altynbekova: Department of Psychiatry and Narcology, S.D. Asfendiarov Kazakh National Medical University, Almaty 050022, Kazakhstan
Anna I. Strelnik: International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, 443016 Samara, Russia
Regina F. Nasyrova: Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia

DOI: https://doi.org/10.3390/biomedicines11051499
Journal volume & issue: Vol. 11, no. 5
p. 1499

Abstract

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Valproic acid (VPA) and its salts (sodium calcium magnesium and orotic) are psychotropic drugs that are widely used in neurology and psychiatry. The long-term use of VPA increases the risk of developing adverse drug reactions (ADRs), among which metabolic syndrome (MetS) plays a special role. MetS belongs to a cluster of metabolic conditions such as abdominal obesity, high blood pressure, high blood glucose, high serum triglycerides, and low serum high-density lipoprotein. Valproate-induced MetS (VPA-MetS) is a common ADR that needs an updated multidisciplinary approach to its prevention and diagnosis. In this review, we consider the results of studies of blood (serum and plasma) and the urinary biomarkers of VPA-MetS. These metabolic biomarkers may provide the key to the development of a new multidisciplinary personalized strategy for the prevention and diagnosis of VPA-MetS in patients with neurological diseases, psychiatric disorders, and addiction diseases.

Published in Biomedicines

ISSN: 2227-9059 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/biomedicines

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