Synthesis and characterization of a new complex based on antibiotic: Zirconium complex

Abstract

It is well known that sulfonamide derivatives, through exchange of different functional groups without modification of the –S(O)2N(H)– function, can exhibit a wide variety of pharmacological activities. In addition, some metal complexes of these ligands have been prepared to promote rapid healing of burns in humans and animals, for example, the complex of Zn(ii) sulfadiazine. Their effectiveness does not depend solely on the slow release of the metal ion, but rather strongly on the nature of the material to which the metal is bound. Given the ability of sulfonamide derivatives to coordinate with metal atoms in different ways, considerable interest in the synthesis and structural aspects of new complexes has arisen. These results confirm that the significant chemical capacity of sulfonamides to act as ligands is based on the acidity of its –S(O)2N(H)– function, which gives a donor anionic ligand, allied to the presence of atoms vicinal to nitrogen, sulfur or oxygen of the heterocyclic ring, which provide the stereochemical requirements for the realization of complexes with monodentate ligand, chelating agent or bridging ligand, providing monomeric structures, dimeric arrangements and polymers. In addition, the aromatic amino group is responsible for the chemical versatility of the sulfonamides, since it can act as a coordination site, as well as a reactive site for chemical modifications of sulfonamide complexes with very interesting biological purposes. In the present work, the synthesis and structure of a novel sulfanilamide complex: nitro (4-aminobenzenesulfonamide) zirconium was presented. Characterization of the complex was performed by infrared spectroscopic, thermogravimetric and X-ray diffraction analysis.

Keywords

• single-crystal
• x-ray study
• hydrothermal synthesis
• zirconium sulfanilamide