Prevalence and Impact of HMOX1 Polymorphism (rs2071746: A &gt; T) in Indian Sickle Cell Disease Patients

Hareram Pandey; Kanwaljeet Singh; Ravi Ranjan; Jasmita Dass; Seema Tyagi; Tulika Seth; Renu Saxena; Manoranjan Mahapatra

doi:10.1055/s-0043-1770068

Journal of Laboratory Physicians (Dec 2023)

Prevalence and Impact of HMOX1 Polymorphism (rs2071746: A > T) in Indian Sickle Cell Disease Patients

Hareram Pandey,
Kanwaljeet Singh,
Ravi Ranjan,
Jasmita Dass,
Seema Tyagi,
Tulika Seth,
Renu Saxena,
Manoranjan Mahapatra

Affiliations

Hareram Pandey: Department of Hematology, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Kanwaljeet Singh: Lab Sciences & Molecular Medicine, Army Hospital Research and Referral, Delhi Cantt, Delhi, India
Ravi Ranjan: ORCiD; Department of Hematology, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Jasmita Dass: Department of Hematology, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Seema Tyagi: Department of Hematology, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Tulika Seth: Department of Hematology, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Renu Saxena: Department of Hematology, All India Institute of Medical Sciences (AIIMS), New Delhi, India
Manoranjan Mahapatra: Department of Hematology, All India Institute of Medical Sciences (AIIMS), New Delhi, India

DOI: https://doi.org/10.1055/s-0043-1770068
Journal volume & issue: Vol. 15, no. 04
pp. 583 – 589

Abstract

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Introduction Fetal hemoglobin (HbF) levels play significant role in lowering down the morbidity and mortality in sickle cell disease (SCD) patients. Coinheritance of heme oxygenase-1 (HMOX1) rs2071746:A > T polymorphism may contribute to variable HbF levels in Indian SCD patients.

Published in Journal of Laboratory Physicians

ISSN: 0974-2727 (Print); 0974-7826 (Online)
Publisher: Thieme Medical and Scientific Publishers Pvt. Ltd.
Country of publisher: India
LCC subjects: Medicine
Website: https://www.thieme.in/journal-of-laboratory-physicians

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