White blood cell-to-haemoglobin ratio as a predictor of 30-day mortality in ICU patients with pulmonary hypertension: a MIMIC-IV database study

Abstract

Abstract Background and objective : The white blood cell-to-haemoglobin ratio (WHR) is a comprehensive indicator of inflammation and anaemia status. However, the relationship between the WHR and the risk of 30-day mortality among intensive care unit (ICU) patients with pulmonary hypertension (PH) remains unclear. The purpose of this study was to investigate the association between the WHR and 30-day mortality in critically ill patients with PH. Methods Clinical data of patients with PH were extracted from the MIMIC-IV (2.2) database. Restricted cubic splines and logistic regression analysis were used to investigate the relationship between the WHR and 30-day mortality. Subgroup analysis was used to assess the robustness of the results. Results A total of 451 patients with PH were enrolled, with 78 (17.3%) dying within 30 days. Restricted cubic spline analysis revealed a linear relationship between the WHR and 30-day mortality. Logistic regression analysis revealed the WHR was an independent predictor for 30-day mortality in critically ill patients with PH (OR, 1.58; 95% CI, 1.05–2.37; P = 0.028). The AUC of the WHR was 0.646 (95% CI: 0.60–0.69). Conclusions A higher WHR was an independent predictor for 30-day mortality in critically ill patients with PH. Clinical trial number Not applicable.

Keywords

• White blood cell-to-haemoglobin ratio
• Pulmonary hypertension
• Predictor
• 30-day mortality
• Intensive care unit