Fe3O4-magnetic nanoparticles from essential oil of Orange peel catalyzed Green synthesis of pyridine derivatives: study of antioxidant activity of some synthezised compounds

Abstract

In this research functionalized pyridines are produced from the reaction of propiolates, N,N′-di-tert-butylcarbodiimide, -bromo ketone and triphenylphosphin in the presence of catalytic amount of Fe3O4-MNPs at 70 oC in water as green solvent. In this research the Fe3O4-MNPs is prepared from water essential oil extracted of orange peel. The good yield of product, short reaction time, easy separation of catalyst, performing the reaction in water as green solvent, easy separation of product by filtration and green synthesis of catalyst are advantages of this method in synthesis of pyridine derivatives. It should be mentioned, these reactions have very low yields without any catalyst. Also, in this research the antioxidant activity of some new synthesized pyridines such as 5b, 5c, 5d and 5e were investigated by DPPH radical trapping and reducing potential testes of ferric ion. The results were compared with the synthetic antioxidants (TBHQ and BHT).

Keywords

• pyridine
• green solvent
• fe3o4-mnps
• di-tert-butylcarbodiimide