Nature Communications (Jan 2019)

Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells

  • Muneaki Nakamura,
  • Prashanth Srinivasan,
  • Michael Chavez,
  • Matthew A. Carter,
  • Antonia A. Dominguez,
  • Marie La Russa,
  • Matthew B. Lau,
  • Timothy R. Abbott,
  • Xiaoshu Xu,
  • Dehua Zhao,
  • Yuchen Gao,
  • Nathan H. Kipniss,
  • Christina D. Smolke,
  • Joseph Bondy-Denomy,
  • Lei S. Qi

DOI
https://doi.org/10.1038/s41467-018-08158-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Anti-CRISPR proteins derived from phage can abrogate CRISPR activity. The authors repurpose these molecules for demonstrating genomic write-protection and pre-programmed gene expression circuits.