Nature Communications (Aug 2023)
Association between vmPFC gray matter volume and smoking initiation in adolescents
- Shitong Xiang,
- Tianye Jia,
- Chao Xie,
- Wei Cheng,
- Bader Chaarani,
- Tobias Banaschewski,
- Gareth J. Barker,
- Arun L. W. Bokde,
- Christian Büchel,
- Sylvane Desrivières,
- Herta Flor,
- Antoine Grigis,
- Penny A. Gowland,
- Rüdiger Brühl,
- Jean-Luc Martinot,
- Marie-Laure Paillère Martinot,
- Frauke Nees,
- Dimitri Papadopoulos Orfanos,
- Luise Poustka,
- Sarah Hohmann,
- Juliane H. Fröhner,
- Michael N. Smolka,
- Nilakshi Vaidya,
- Henrik Walter,
- Robert Whelan,
- Hugh Garavan,
- Gunter Schumann,
- Barbara J. Sahakian,
- Trevor W. Robbins,
- Jianfeng Feng,
- IMAGEN Consortium
Affiliations
- Shitong Xiang
- Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University
- Tianye Jia
- Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University
- Chao Xie
- Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University
- Wei Cheng
- Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University
- Bader Chaarani
- Departments of Psychiatry and Psychology, University of Vermont
- Tobias Banaschewski
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Gareth J. Barker
- Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Arun L. W. Bokde
- Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin
- Christian Büchel
- University Medical Centre Hamburg-Eppendorf
- Sylvane Desrivières
- Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Herta Flor
- Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Antoine Grigis
- NeuroSpin, C.E.A., Université Paris-Saclay
- Penny A. Gowland
- Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham
- Rüdiger Brühl
- Physikalisch-Technische Bundesanstalt (PTB)
- Jean-Luc Martinot
- Institut National de la Santé et de la Recherche Médicale, INSERM U1299 ‘Trajectoires développementales en psychiatrie’, Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010
- Marie-Laure Paillère Martinot
- Institut National de la Santé et de la Recherche Médicale, INSERM U1299 ‘Trajectoires développementales en psychiatrie’, Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010
- Frauke Nees
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Dimitri Papadopoulos Orfanos
- Department of Psychology, School of Social Sciences, University of Mannheim
- Luise Poustka
- Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg
- Sarah Hohmann
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Juliane H. Fröhner
- Department of Psychiatry and Psychotherapy, Technische Universität Dresden
- Michael N. Smolka
- Department of Psychiatry and Psychotherapy, Technische Universität Dresden
- Nilakshi Vaidya
- Department of Psychiatry and Neurosciences, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health
- Henrik Walter
- Department of Psychiatry and Neurosciences, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health
- Robert Whelan
- School of Psychology and Global Brain Health Institute, Trinity College Dublin
- Hugh Garavan
- Departments of Psychiatry and Psychology, University of Vermont
- Gunter Schumann
- Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University
- Barbara J. Sahakian
- Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University
- Trevor W. Robbins
- Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University
- Jianfeng Feng
- Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University
- IMAGEN Consortium
- DOI
- https://doi.org/10.1038/s41467-023-40079-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Abstract Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.
