Nature Communications (Aug 2020)

Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates

  • Louis Faure,
  • Yiqiao Wang,
  • Maria Eleni Kastriti,
  • Paula Fontanet,
  • Kylie K. Y. Cheung,
  • Charles Petitpré,
  • Haohao Wu,
  • Lynn Linyu Sun,
  • Karen Runge,
  • Laura Croci,
  • Mark A. Landy,
  • Helen C. Lai,
  • Gian Giacomo Consalez,
  • Antoine de Chevigny,
  • François Lallemend,
  • Igor Adameyko,
  • Saida Hadjab

DOI
https://doi.org/10.1038/s41467-020-17929-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

Read online

The diversity of primary sensory neurons and how fate choice is determined is unclear. Here, the authors use single cell RNA sequencing analysis of early murine somatosensory neurons to show that sensory neuron diversity is achieved by a transition through a bi-potential intermediate state.