Nature Communications (Nov 2021)

Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice

  • Xiaxia Xu,
  • Lingzhen Song,
  • Rebecca Kringel,
  • Ileana L. Hanganu-Opatz

DOI
https://doi.org/10.1038/s41467-021-27114-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 17

Abstract

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The authors show that mice that mimic the dual genetic-environmental etiology of psychiatric risk have poor lateral entorhinal cortex-dependent recognition memory already at pre-juvenile age and abnormal communication within LECHP-PFC networks throughout development.