Nature Communications (Mar 2020)
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension
- Hebah A. Sindi,
- Giusy Russomanno,
- Sandro Satta,
- Vahitha B. Abdul-Salam,
- Kyeong Beom Jo,
- Basma Qazi-Chaudhry,
- Alexander J. Ainscough,
- Robert Szulcek,
- Harm Jan Bogaard,
- Claire C. Morgan,
- Soni S. Pullamsetti,
- Mai M. Alzaydi,
- Christopher J. Rhodes,
- Roberto Piva,
- Christina A. Eichstaedt,
- Ekkehard Grünig,
- Martin R. Wilkins,
- Beata Wojciak-Stothard
Affiliations
- Hebah A. Sindi
- National Heart and Lung Institute, Imperial College London
- Giusy Russomanno
- National Heart and Lung Institute, Imperial College London
- Sandro Satta
- National Heart and Lung Institute, Imperial College London
- Vahitha B. Abdul-Salam
- National Heart and Lung Institute, Imperial College London
- Kyeong Beom Jo
- National Heart and Lung Institute, Imperial College London
- Basma Qazi-Chaudhry
- Department of Physics, King’s College London UK
- Alexander J. Ainscough
- National Heart and Lung Institute, Imperial College London
- Robert Szulcek
- Amsterdam UMC, VU University Medical Center, Department of Pulmonary Diseases, Amsterdam Cardiovascular Sciences (ACS)
- Harm Jan Bogaard
- Amsterdam UMC, VU University Medical Center, Department of Pulmonary Diseases, Amsterdam Cardiovascular Sciences (ACS)
- Claire C. Morgan
- National Heart and Lung Institute, Imperial College London
- Soni S. Pullamsetti
- Max Planck Institute for Heart and Lung Research, Department of Lung Development and Remodeling, Member of the German Center for Lung Research (DZL)
- Mai M. Alzaydi
- National Heart and Lung Institute, Imperial College London
- Christopher J. Rhodes
- National Heart and Lung Institute, Imperial College London
- Roberto Piva
- Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin
- Christina A. Eichstaedt
- Centre for Pulmonary Hypertension, Thoraxclinic, Institute for Human Genetics, University of Heidelberg, Translational Lung Research Center (TLRC), German Center for Lung Research (DZL)
- Ekkehard Grünig
- Centre for Pulmonary Hypertension, Thoraxclinic, Institute for Human Genetics, University of Heidelberg, Translational Lung Research Center (TLRC), German Center for Lung Research (DZL)
- Martin R. Wilkins
- National Heart and Lung Institute, Imperial College London
- Beata Wojciak-Stothard
- National Heart and Lung Institute, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-020-14966-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Pulmonary arterial hypertension is a severe lung disease characterised by progressive vascular remodelling. Here, the authors show that reduced signalling of flow-activated transcription factor KLF2 is a common feature of human PAH and that KLF2-regulated exosomal miRNAs have a therapeutic effect.
