Reumatismo (Sep 2011)

GENETICS OF PSORIASIS AND PSORIATIC ARTHRITIS

  • V. Ibba,
  • M. Piga,
  • G. Porru,
  • G. Passiu,
  • A. Mameli,
  • A. Vacca,
  • A. Cauli,
  • A. Mathieu,
  • V. Mura,
  • S. Anna

DOI
https://doi.org/10.4081/reumatismo.2007.1s.25
Journal volume & issue
Vol. 59, no. 1s
pp. 25 – 27

Abstract

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Psoriasis and psoriatic arthritis are linked diseases characterised by (distinct ?) immune-mediated pathogenetic mechanisms and by a genetic background interacting with environmental factors. Some candidate susceptibility genes have been studied extensively; they include HLA genes, genes within the HLA region and genes outside the HLA region; among them corneodesmosin and other genes of PSORS1 region, MICA and TNF-a polymorphisms. The main findings in the literature are discussed. Key words: Genetics, psosriasis, psoriatic arthritis