Serum levels of resistin and its relationship with some pro-inflammatory cytokines in a cohort of Egyptian patients with Alzheimer's disease

Abstract

Objectives: The objective of this study was to determine whether plasma resistin levels would be useful in the diagnosis of patients with AD and to investigate the relationships between resistin and IL-6, TNF-α, and CRP. Patients and methods: Ninety five patients with Alzheimer disease(AD) aged 65 years or more and 35 sex and age matched healthy subjects were included in the study as controls.We excluded participants with DM, hypertension, liver or renal failure, ischemic heart disease, congestive heart failure, stroke, thyroid disorders, active infection or other inflammatory diseases, chronic use of anti-inflammatory drugs.The diagnosis of AD was determined based on the Diagnostic and Statistical Manual of Mental Disorders 4th edition, text revision criteria and mini mental state examination (MMSE). Serum resistin, IL-6, TNF-α, and CRP were measured for all participants. Results: Serum levels of resistin, IL-6, CRP, and TNF-α were significantly higher in patients with AD than healthy controls. The resistin levels were positively correlated with the levels of IL-6, CRP, and TNF-α. MMSE was negatively correlated with IL-6, CRP, and TNF-α, whereas the correlation is only significant with CRP. A high statistically negative correlation was found between MMSE and resistin levels. Conclusion: We concluded that serum resistin may be linked to peripheral inflammatory markers which are associated with AD.

Keywords

• Alzheimer disease
• Resistin
• CRP
• TNF-α
• IL-6
• Pro-inflammatory cytokines