Alternate subunit assembly diversifies the function of a bacterial toxin

Casey C. Fowler; Gabrielle Stack; Xuyao Jiao; Maria Lara-Tejero; Jorge E. Galán

doi:10.1038/s41467-019-11592-0

Nature Communications (Aug 2019)

Alternate subunit assembly diversifies the function of a bacterial toxin

Casey C. Fowler,
Gabrielle Stack,
Xuyao Jiao,
Maria Lara-Tejero,
Jorge E. Galán

Affiliations

Casey C. Fowler: Department of Microbial Pathogenesis, Yale University School of Medicine
Gabrielle Stack: Department of Microbial Pathogenesis, Yale University School of Medicine
Xuyao Jiao: Department of Microbial Pathogenesis, Yale University School of Medicine
Maria Lara-Tejero: Department of Microbial Pathogenesis, Yale University School of Medicine
Jorge E. Galán: Department of Microbial Pathogenesis, Yale University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-11592-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Salmonella Typhi produces the typhoid toxin. Here, Fowler et al. show that S. Typhi produces two forms of typhoid toxin that are differentially regulated and display different trafficking properties and different effects when administered to laboratory animals.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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