The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: The second phase of the archive of digital records
Tomoko Sakai,
Junichi Hata,
Yuta Shintaku,
Hiroki Ohta,
Kazumi Sogabe,
Susumu Mori,
Takako Miyabe-Nishiwaki,
Hirotaka James Okano,
Yuzuru Hamada,
Toshiyuki Hirabayashi,
Takafumi Minamimoto,
Norihiro Sadato,
Hideyuki Okano,
Kenichi Oishi
Affiliations
Tomoko Sakai
Corresponding author at: Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.; Department of Physiology, Keio University School of Medicine, Tokyo, Japan; Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, Japan; Division of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan
Junichi Hata
Department of Physiology, Keio University School of Medicine, Tokyo, Japan; Division of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan; Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan; RIKEN Center for Brain Science, Laboratory for Marmoset Neural Architecture, Wako, Saitama, Japan
Yuta Shintaku
Wildlife Research Center, Kyoto University, Kyoto, Japan; Japan Monkey Centre, Inuyama, Aichi, Japan
Hiroki Ohta
Division of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan
Kazumi Sogabe
Division of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan; Department of Radiological Technology, Faculty of Medical Technology, Teikyo University, Tokyo, Japan
Susumu Mori
The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kenney Krieger Institute, Baltimore, MD, USA
Takako Miyabe-Nishiwaki
Center for the Evolutionary Origins of Human Behavior, Kyoto University, Kyoto, Japan
Hirotaka James Okano
Division of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan
Yuzuru Hamada
National Primate Research Institute of Thailand, Chulalongkorn University, Kaengkhoi, Thailand
Toshiyuki Hirabayashi
Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, Japan
Takafumi Minamimoto
Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, Japan
Norihiro Sadato
The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa, Japan; Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Japan
Hideyuki Okano
Department of Physiology, Keio University School of Medicine, Tokyo, Japan; RIKEN Center for Brain Science, Laboratory for Marmoset Neural Architecture, Wako, Saitama, Japan
Kenichi Oishi
The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
A comparison of neuroanatomical features of the brain between humans and our evolutionary relatives, nonhuman primates, is key to understanding the human brain system and the neural basis of mental and neurological disorders. Although most comparative MRI studies of human and nonhuman primate brains have been based on brains of primates that had been used as subjects in experiments, it is essential to investigate various species of nonhuman primates in order to elucidate and interpret the diversity of neuroanatomy features among humans and nonhuman primates. To develop a research platform for this purpose, it is necessary to harmonize the scientific contributions of studies with the standards of animal ethics, animal welfare, and the conservation of brain information for long-term continuation of the field. In previous research, we first developed a gated data-repository of anatomical images obtained using 9.4-T ex vivo MRI of postmortem brain samples from 12 nonhuman primate species, and which are stored at the Japan Monkey Centre. In the present study, as a second phase, we released a collection of T2-weighted images and diffusion tensor images obtained in nine species: white-throated capuchin, Bolivian squirrel monkey, stump-tailed macaque, Tibet monkey, Sykes’ monkey, Assamese macaque, pig-tailed macaque, crested macaque, and chimpanzee. Our image repository should facilitate scientific discoveries in the field of comparative neuroscience. This repository can also promote animal ethics and animal welfare in experiments with nonhuman primate models by optimizing methods for in vivo and ex vivo MRI scanning of brains and supporting veterinary neuroradiological education. In addition, the repository is expected to contribute to conservation, preserving information about the brains of various primates, including endangered species, in a permanent digital form.
