Nature Communications (Feb 2018)

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair

  • Wei-Ting Lu,
  • Ben R. Hawley,
  • George L. Skalka,
  • Robert A. Baldock,
  • Ewan M. Smith,
  • Aldo S. Bader,
  • Michal Malewicz,
  • Felicity Z. Watts,
  • Ania Wilczynska,
  • Martin Bushell

DOI
https://doi.org/10.1038/s41467-018-02893-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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The mechanism through which Drosha and Dicer affect DNA repair is not clear. Here the authors use a high-throughput approach to uncover the role of Drosha in promoting DNA:RNA hybrids at DNA damaged sites.