Medical applications of ternary nanocomposites based on hydroxyapatite/ytterbium oxide/graphene oxide: potential bone tissue engineering and antibacterial properties

Hanan A. Albalwi; Mehrez E. El-Naggar; Manal Abou Taleb; Abul Kalam; Noweir Ahmad Alghamdi; Mervat S. Mostafa; Salem Salem; M. Afifi

Journal of Materials Research and Technology (May 2022)

Medical applications of ternary nanocomposites based on hydroxyapatite/ytterbium oxide/graphene oxide: potential bone tissue engineering and antibacterial properties

Hanan A. Albalwi,
Mehrez E. El-Naggar,
Manal Abou Taleb,
Abul Kalam,
Noweir Ahmad Alghamdi,
Mervat S. Mostafa,
Salem Salem,
M. Afifi

Affiliations

Hanan A. Albalwi: Department of Chemistry, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia
Mehrez E. El-Naggar: Institute of Textile Research and Technology, National Research Centre, Dokki, Cairo, 16221, Egypt; Corresponding author.
Manal Abou Taleb: Department of Chemistry, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia; Department of Polymer Chemistry, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Nasr City, P.O. Box 7551, Cairo 11762, Egypt
Abul Kalam: Research Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia; Department of Chemistry, College of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia
Noweir Ahmad Alghamdi: Department of Physics, Faculty of Science, Albaha University, Alaqiq 65779, Saudi Arabia
Mervat S. Mostafa: Science and Technology Center of Excellence (STCE), Ministry of Military Production, Cairo, Egypt
Salem Salem: Department of Biochemistry and Clinical Biochemistry, Military Medical Academy, Egypt
M. Afifi: Faculty of Nanotechnology for Postgraduate Studies, Cairo University, El-Sheikh Zayed 12588, Egypt

Journal volume & issue: Vol. 18
pp. 4834 – 4845

Abstract

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The spreading of diseases that cause major bone defects urges the need for fabricating bone substitutes. Hydroxyapatite (HAP)/ytterbium oxide (Yb2O3)/graphene oxide (GO) nanocomposite is fabricated and studied for its bioactivity, biocompatibility, microhardness, and antimicrobial activity to be used as bone replacement biomaterial. Moreover, the SEM micrographs revealed the improvement in scaffold porosity and biocompatibility, showing a particle size range from 0.1 to 1.5 μm. HAP/Yb2O3/GO shows enhanced roughness parameters in which the roughness average value reached 40.5 nm. Furthermore, the improved osteoblast cells attachment and proliferation obtained by HAP/Yb2O3/GO nanocomposite is confirmed via cell viability test the high value of 97.7 ± 2.1%. HAP/Yb2O3/GO shows antibacterial properties against Escherichia coli and Staphylococcus aureus that evidenced with inhibition zone 12.5 ± 1 mm and 11.8 ± 1.1 mm, respectively. Besides, HAP/Yb2O3/GO showed the highest microhardness values of 3.4 ± 0.2 GPa.

Published in Journal of Materials Research and Technology

ISSN: 2238-7854 (Print); 2214-0697 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Mining engineering. Metallurgy
Website: https://www.journals.elsevier.com/journal-of-materials-research-and-technology/

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