肥胖相关慢性炎症与代谢性脑血管病 Obesity-Related Chronic Inflammation and Cerebro-Metabolic Disease

Abstract

脑血管病目前已成为全球第二大死亡原因，其发病风险主要归因于代谢紊乱。本文就肥胖相关慢性炎症与代谢性脑血管病的发病机制进行综述。肥胖状态下免疫细胞聚集、促炎因子分泌增加、血管内皮损伤等是代谢性脑血管病的重要致病机制。以炎症为治疗靶点的生活方式干预、药物免疫治疗及减重抗炎治疗等新型、有效的防治策略，有望为降低代谢性脑血管病的发病率，提高患者的生存率和生活质量提供参考依据。 Abstract: Cerebrovascular disease has become the second cause of death worldwide, and its risk is mainly attributed to metabolic disorders. This paper reviewed the pathogenesis of obesity-related chronic inflammation and cerebro-metabolic disease. The aggregation of immune cells, heightened secretion of pro-inflammatory factors and vascular endothelial injury are important pathogenic mechanisms of cerebro-metabolic disease in obesity state. New and effective prevention and treatment strategies such as lifestyle intervention, drug immunotherapy and weight reduction anti-inflammatory therapy targeting inflammation are expected to provide reference for reducing the incidence of cerebro-metabolic diseases while enhancing both patient survival rates and quality of life.

Keywords

• 肥胖
• 慢性炎症
• 代谢性脑血管病
• 脂肪相关巨噬细胞
• 抗炎治疗
• obesity
• chronic inflammation
• cerebro-metabolic disease
• adipose tissue macrophage
• anti-inflammatory therapy