Nature Communications (Nov 2017)
NOTCH1 is a mechanosensor in adult arteries
- Julia J. Mack,
- Thiago S. Mosqueiro,
- Brian J. Archer,
- William M. Jones,
- Hannah Sunshine,
- Guido C. Faas,
- Anais Briot,
- Raquel L. Aragón,
- Trent Su,
- Milagros C. Romay,
- Austin I. McDonald,
- Cheng-Hsiang Kuo,
- Carlos O. Lizama,
- Timothy F. Lane,
- Ann C. Zovein,
- Yun Fang,
- Elizabeth J. Tarling,
- Thomas Q. de Aguiar Vallim,
- Mohamad Navab,
- Alan M. Fogelman,
- Louis S. Bouchard,
- M. Luisa Iruela-Arispe
Affiliations
- Julia J. Mack
- Department of Molecular, Cell & Developmental Biology, University of California
- Thiago S. Mosqueiro
- Institute for Quantitative and Computational Biology, University of California
- Brian J. Archer
- Department of Bioengineering, University of California
- William M. Jones
- Department of Molecular, Cell & Developmental Biology, University of California
- Hannah Sunshine
- Interdepartmental Graduate Program in Molecular, Cellular and Integrative Physiology, University of California
- Guido C. Faas
- Department of Neurology, David Geffen School of Medicine, University of California
- Anais Briot
- Department of Molecular, Cell & Developmental Biology, University of California
- Raquel L. Aragón
- Molecular Biology Interdisciplinary Graduate Program, Molecular Biology Institute, University of California
- Trent Su
- Department of Biological Chemistry, University of California
- Milagros C. Romay
- Department of Molecular, Cell & Developmental Biology, University of California
- Austin I. McDonald
- Molecular Biology Interdisciplinary Graduate Program, Molecular Biology Institute, University of California
- Cheng-Hsiang Kuo
- Department of Medicine, University of Chicago
- Carlos O. Lizama
- Cardiovascular Research Institute, University of California
- Timothy F. Lane
- Department of Biological Chemistry, University of California
- Ann C. Zovein
- Cardiovascular Research Institute, University of California
- Yun Fang
- Department of Medicine, University of Chicago
- Elizabeth J. Tarling
- Department of Biological Chemistry, University of California
- Thomas Q. de Aguiar Vallim
- Department of Biological Chemistry, University of California
- Mohamad Navab
- Department of Medicine, David Geffen School of Medicine, University of California
- Alan M. Fogelman
- Department of Medicine, David Geffen School of Medicine, University of California
- Louis S. Bouchard
- Department of Bioengineering, University of California
- M. Luisa Iruela-Arispe
- Department of Molecular, Cell & Developmental Biology, University of California
- DOI
- https://doi.org/10.1038/s41467-017-01741-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 19
Abstract
The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.
