BMC Geriatrics (Mar 2023)

"SARCOPENIA MEASURED BY ULTRASOUND IN HOSPITALIZED OLDER ADULTS" (ECOSARC): multi-centre, prospective observational study protocol

  • Esther López Jiménez,
  • Marta Neira Álvarez,
  • Raquel Ramírez Martín,
  • Cristina Alonso Bouzón,
  • María Solange Amor Andrés,
  • Cristina Bermejo Boixareu,
  • Fátima Brañas,
  • Rocío Menéndez Colino,
  • Estefanía Arias Muñana,
  • Marta Checa López,
  • Concha Grau Jiménez,
  • Patricia Pérez Rodríguez,
  • María Alcantud Ibáñez,
  • Brian Vasquez Brolen,
  • Juan Oliva,
  • Luz María Peña Longobardo,
  • Rubén Alcantud Córcoles,
  • Elisa Belén Cortés Zamora,
  • Elena Gómez Jiménez,
  • Luis Romero Rizos,
  • Almudena Avendaño Céspedes,
  • Carmen Rosa Hernández Socorro,
  • Pedro Abizanda

DOI
https://doi.org/10.1186/s12877-023-03891-5
Journal volume & issue
Vol. 23, no. 1
pp. 1 – 10

Abstract

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Abstract Background Measurement of muscle mass and function, and thereafter, screening and diagnosis of sarcopenia, is a challenge and a need in hospitalized older adults. However, it is difficult in complex real-world old patients, because usually they are unable to collaborate with clinical, functional, and imaging testing. Ultrasound measurement of quadriceps rectus femoris (QRF) provides a non-invasive, real-time assessment of muscle quantity and quality, and is highly acceptable to participants with excellent inter-rater and intra-rater variability. However, normative data, protocol standardization, and association with longitudinal outcomes, needs further research and consensus. Methods Prospective exploratory multicenter study in older adults admitted to Acute Geriatric Units (AGUs) for medical reasons. 157 subjects from 7 AGUs of Spain were recruited between May 2019 and January 2022. Muscle ultrasound measurements of the anterior vastus of the QRF were acquired on admission and on discharge, using a previously validated protocol, using a Chieson model ECO2 ultrasound system (Chieson Medical Technologies, Co. Ltd, Wimxu District Wuxi, Jiangsu, China). Measurements included the cross-sectional area, muscle thickness in longitudinal view, intramuscular central tendon thickness, echogenicity, and the presence or absence of edema and fasciculations. Functional, nutritional, and DXA measurements were provided. Clinical follow-up was completed at discharge, and 30 and 90 days after discharge. Variations between hospital admission and discharge ultrasound values, and the relationship with clinical variables, will be analyzed using paired t-tests, Wilcoxon tests, or Mc Nemar chi-square tests when necessary. Prevalence of sarcopenia will be calculated, as well as sensitivity and specificity of ultrasound measurements to determine sarcopenia. Kappa analysis will be used to analyze the concordance between measurements, and sensitivity analysis will be conducted for each participating center. Discussion The results obtained will be of great interest to the scientific geriatric community to assess the utility and validity of ultrasound measurements for the detection and follow-up of sarcopenia in hospitalized older adults, and its association with adverse outcomes. Trial registration NCT05113758. Registration date: November 9th 2021. Retrospectively registered.

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