The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans

Shuixiu Li; Yajing Zhao; Yishan Zhang; Yanli Zhang; Zhanpeng Zhang; Chuanyan Tang; Luobei Weng; Xiaohong Chen; Gehua Zhang; Hong Zhang

doi:10.1038/s41467-021-26313-9

Nature Communications (Oct 2021)

The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans

Shuixiu Li,
Yajing Zhao,
Yishan Zhang,
Yanli Zhang,
Zhanpeng Zhang,
Chuanyan Tang,
Luobei Weng,
Xiaohong Chen,
Gehua Zhang,
Hong Zhang

Affiliations

Shuixiu Li: Department of Dermatology, The First Affiliated Hospital of Jinan University
Yajing Zhao: Department of Dermatology, The First Affiliated Hospital of Jinan University
Yishan Zhang: Department of Dermatology, The First Affiliated Hospital of Jinan University
Yanli Zhang: Department of Dermatology, The First Affiliated Hospital of Jinan University
Zhanpeng Zhang: Department of Dermatology, The First Affiliated Hospital of Jinan University
Chuanyan Tang: Department of Dermatology, The First Affiliated Hospital of Jinan University
Luobei Weng: Department of Dermatology, The First Affiliated Hospital of Jinan University
Xiaohong Chen: Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-Sen University
Gehua Zhang: Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-Sen University
Hong Zhang: Department of Dermatology, The First Affiliated Hospital of Jinan University

DOI: https://doi.org/10.1038/s41467-021-26313-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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F1Fo-ATP synthase is a key enzyme for energy production in fungi. Here, the authors show that the δ subunit of the enzyme is required for Candida albicans lethal infection and represents a potential therapeutic target.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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