Role of long non-coding RNA SNHG16 in different gastrointestinal malignancies

Abstract

Long non-coding RNAs(lncRNAs) can play an important role in the occurrence and development of human cancers as oncogenes or tumor suppressors, and are considered as potential markers for diagnosing cancer and judging prognosis. Small nucleolar RNA host gene 16(SNHG16) located on chromosome 17 17q25.1 is a novel tumor-associated lncRNA, and have been found to be abnormally expressed in a variety of malignant tumors. Meanwhile, high expression of SNHG16 is associated with the clinical and pathological features of patients, and regulates cell proliferation, apoptosis, invasion, metastasis, and affects lipid metabolism and chemoresistance through a variety of potential mechanisms. These evidences suggest that SNHG16 may be a promising cancer biomarker and therapeutic target. In this review, we summarize the biological functions, related mechanisms and potential clinical significance of SNHG16 in various gastrointestinal malignancies.

Keywords

• long non-coding rna
• snhg16
• gastrointestinal malignancy
• esophageal cancer
• hepatocellular carcinoma
• cholangiocarcinoma
• gastric cancer
• pancreatic cancer