Fast T1 mapping MRI in preclinical and clinical settings using subspace-constrained joint-domain reconstructions

Abstract

This work aims to develop fast T1 mapping methods for preclinical and clinical scanners based on subspace-constrained reconstructions. Two sequences are explored for rapid T1 characterizations: 1) Interleaved spatiotemporal encoding incorporating variable repetition times. 2) Inversion recovery gradient echo with random sampling of the phase-encoding (PE) dimension. For both sequences, the subspace reconstruction of the signal recovery was applied, to jointly reconstruct the down-sampled images while characterizing the T1 relaxation. In vivo scans on human brains and abdomens confirmed the efficiency of the proposed methods, including compatibility with breath-holding. In addition, Scans on animals with abdominal tumors and dynamic contrast-enhanced T1 mapping on kidneys support the applicability of the proposed methods also in preclinical settings.

Keywords

• T1 mapping
• Subspace-constrained reconstructions
• IR GRE
• SPEN
• Dynamic contrast enhancement
• Pancreatic cancer