Intestinal Research (Jul 2019)
Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn’s disease in Asia
- Choon Jin Ooi,
- Ida Hilmi,
- Rupa Banerjee,
- Sai Wei Chuah,
- Siew Chien Ng,
- Shu Chen Wei,
- Govind K Makharia,
- Pises Pisespongsa,
- Min Hu Chen,
- Zhi Hua Ran,
- Byong Duk Ye,
- Dong Il Park,
- Khoon Lin Ling,
- David Ong,
- Vineet Ahuja,
- Khean Lee Goh,
- Jose Sollano,
- Wee Chian Lim,
- Wai Keung Leung,
- Raja Affendi Raja Ali,
- Deng Chyang Wu,
- Evan Ong,
- Nazri Mustaffa,
- Julajak Limsrivilai,
- Tadakazu Hisamatsu,
- Suk Kyun Yang,
- Qin Ouyang,
- Richard Geary,
- Janaka H De Silva,
- Rungsun Rerknimitr,
- Marcellus Simadibrata,
- Murdani Abdullah,
- Rupert WL Leong
Affiliations
- Choon Jin Ooi
- Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore
- Ida Hilmi
- Department of Medicine, Faculty of Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia
- Rupa Banerjee
- Asian Institute of Gastroenterology, New Delhi, India
- Sai Wei Chuah
- Gleneagles Medical Centre, Singapore
- Siew Chien Ng
- Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
- Shu Chen Wei
- Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
- Govind K Makharia
- Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India
- Pises Pisespongsa
- Gastroenterology and Hepatology, Bumrungrad International University, Bangkok, Thailand
- Min Hu Chen
- Division of Gastroenterology, The First University Hospital, Sun Yat-sen University, Guangzhou, China
- Zhi Hua Ran
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Byong Duk Ye
- Department of Gastroenterology and IBD Center, University of Ulsan College of Medicine, Seoul, Korea
- Dong Il Park
- Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
- Khoon Lin Ling
- Duke-NUS Medical School, Singapore
- David Ong
- Division of Gastroenterology and Hepatology, National University Hospital of Singapore, University Medicine Cluster, Singapore
- Vineet Ahuja
- Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
- Khean Lee Goh
- University of Malaya Specialist Centre, Kuala Lumpur, Malaysia
- Jose Sollano
- Department of Medicine, University of Santo Tomas, Manila, Philippines
- Wee Chian Lim
- Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, Singapore
- Wai Keung Leung
- Division of Gastroenterology and Hepatology, Department of Medicine, University of Hong Kong, Hong Kong
- Raja Affendi Raja Ali
- Faculty of Medicine, UKM Medical and Specialist Centres, The National University of Malaysia, Kuala Lumpur, Malaysia
- Deng Chyang Wu
- Department of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
- Evan Ong
- Department of Medicine, University of Santo Tomas, Manila, Philippines
- Nazri Mustaffa
- Department of Internal Medicine, School of Medical Sciences, Health Campus, Sains University, Kubang Kerian, Malaysia
- Julajak Limsrivilai
- Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
- Tadakazu Hisamatsu
- The Third Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Japan
- Suk Kyun Yang
- Department of Gastroenterology, University of Ulsan College of Medicine, Seoul, Korea
- Qin Ouyang
- Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China
- Richard Geary
- Department of Medicine, University of Otago, Christchurch, New Zealand
- Janaka H De Silva
- Faculty of Medicine, University of Kelaniya, Dalugama, Sri Lanka
- Rungsun Rerknimitr
- Department of Medicine, Chulalongkorn University, Bangkok, Thailand
- Marcellus Simadibrata
- Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
- Murdani Abdullah
- Division of Gastroenterology, Department of Internal Medicine, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
- Rupert WL Leong
- Gastroenterology and Liver Services, Concord Hospital, Sydney, Australia
- DOI
- https://doi.org/10.5217/ir.2019.00026
- Journal volume & issue
-
Vol. 17,
no. 3
pp. 285 – 310
Abstract
The Asia-Pacific Working Group on inflammatory bowel disease (IBD) was established in Cebu, Philippines, under the auspices of the Asian Pacific Association of Gastroenterology with the goal of improving IBD care in Asia. This consensus is carried out in collaboration with Asian Organization for Crohn’s and Colitis. With biologic agents and biosimilars becoming more established, it is necessary to conduct a review on existing literature and establish a consensus on when and how to introduce biologic agents and biosimilars in the conjunction with conventional treatments for ulcerative colitis (UC) and Crohn’s disease (CD) in Asia. These statements also address how pharmacogenetics influence the treatments of UC and CD and provide guidance on response monitoring and strategies to restore loss of response. Finally, the review includes statements on how to manage treatment alongside possible hepatitis B and tuberculosis infections, both common in Asia. These statements have been prepared and voted upon by members of IBD workgroup employing the modified Delphi process. These statements do not intend to be all-encompassing and future revisions are likely as new data continue to emerge.
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