Less than one fifth of Pakistani adolescents, aged 13–15, years achieve recommended activity levels. This systematic review and meta-analysis was conducted to determine a pooled estimate of the prevalence of PA, and to systematically evaluate the literature available on PA among adolescents in Pakistan. A systemic search of databases was conducted. In addition, hand search of references of all the included relevant publications was performed. Random effects meta-analysis was used to get weighted prevalence of PA among adolescents. Quality of undertaken studies was assessed using New-Castle Ottawa Scale. After removing duplicates, reviewing titles and abstracts and screening full texts, 15 articles were included for analysis. All studies were conducted in school setting, with a total sample size of 10,651. Weighted pooled prevalence of PA among adolescents was 36.0% with high heterogeneity (99.28%). Most of the studies met study quality assessment criteria except for comparability of subjects in different outcome groups and assessment of outcome. Prevalence of PA among adolescents is low in Pakistan. Formal strategies are needed for promoting PA among adolescents for their improved health and for reducing future burden of NCDs.