High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy

Abstract

Engineering 3D tissues faces the challenge of adequate vascularisation for nutrient delivery and gas exchange deep inside the construct. Here the authors use surface acoustic waves to create an aligned array of blood vessels in a hyaluronic acid hydrogel and use it to improve function in a mouse hindlimb ischemia model.