ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels

Jeremiah Bernier-Latmani; Cristina Mauri; Rachel Marcone; François Renevey; Stephan Durot; Liqun He; Michael Vanlandewijck; Catherine Maclachlan; Suzel Davanture; Nicola Zamboni; Graham W. Knott; Sanjiv A. Luther; Christer Betsholtz; Mauro Delorenzi; Cathrin Brisken; Tatiana V. Petrova

doi:10.1038/s41467-022-31571-2

Nature Communications (Jul 2022)

ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels

Jeremiah Bernier-Latmani,
Cristina Mauri,
Rachel Marcone,
François Renevey,
Stephan Durot,
Liqun He,
Michael Vanlandewijck,
Catherine Maclachlan,
Suzel Davanture,
Nicola Zamboni,
Graham W. Knott,
Sanjiv A. Luther,
Christer Betsholtz,
Mauro Delorenzi,
Cathrin Brisken,
Tatiana V. Petrova

Affiliations

Jeremiah Bernier-Latmani: Department of Oncology, Ludwig Institute for Cancer Research Lausanne and University of Lausanne
Cristina Mauri: Department of Oncology, Ludwig Institute for Cancer Research Lausanne and University of Lausanne
Rachel Marcone: Bioinformatics Core Facility, SIB Swiss Institute of Bioinformatics
François Renevey: Department of Immunobiology, University of Lausanne
Stephan Durot: Institute of Molecular Systems Biology ETH
Liqun He: Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University
Michael Vanlandewijck: Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University
Catherine Maclachlan: Bio Electron Microscopy Laboratory, School of Life Sciences, EPFL
Suzel Davanture: Department of Oncology, Ludwig Institute for Cancer Research Lausanne and University of Lausanne
Nicola Zamboni: Institute of Molecular Systems Biology ETH
Graham W. Knott: Bio Electron Microscopy Laboratory, School of Life Sciences, EPFL
Sanjiv A. Luther: Department of Immunobiology, University of Lausanne
Christer Betsholtz: Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University
Mauro Delorenzi: Department of Oncology, Ludwig Institute for Cancer Research Lausanne and University of Lausanne
Cathrin Brisken: Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL
Tatiana V. Petrova: Department of Oncology, Ludwig Institute for Cancer Research Lausanne and University of Lausanne

DOI: https://doi.org/10.1038/s41467-022-31571-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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The molecular mechanisms ensuring the specialized structure of small intestinal villus tip blood vessels are incompletely understood. Here the authors show that ADAMTS18+ telocytes maintain a “just-right” level and location of VEGFA signaling on intestinal villus blood vessels, thereby ensuring the presence of endothelial fenestrae for nutrient absorption, while avoiding excessive leakiness and destabilization of villus tip epithelial structures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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