THE EFFECTS OF THE ADJUNCTIVE THERAPY WITH SUBANTIMICROBIAL DOSES OF DOXYCYCLINE IN PATIENTS WITH OSTEOPOROSIS AND CHRONIC PERIODONTITIS

Abstract

The aim of the study was to analyse the periodontal clinical changes generated by the adjunctive periodontal therapy with sub-antimicrobial doses of doxycycline in patients with chronic periodontitis and osteoporosis. Materials and methods: The study was conducted on 26 subjects with chronic periodontitis and osteoporosis, divided in study group (classical periodontal debridement and sub-antimicrobial doses of doxycycline for 3 months) and the control group (classical debridement only). We analysed the probing depth, clinical attachment level, the PBI and PI indices at baseline, in the last day of medication and at 3 months after the drug therapy. Results and discussions: The reduction of the moderate and profound pockets was higher for the study group when compared to the control group. In the control group, the sites with an initial depth of 0-3mm presented a slight attachment loss at 3 and 6 months, while the same depth sites in the study group presented a slight attachment gain. Conclusions: The therapy with sub-antimicrobial doses of doxycycline generated significant clinical improvement in patients with chronic periodontitis and osteoporosis, an improvement which can reduce the necessity of surgical procedures.

Keywords

• chronic periodontitis
• doxycycline
• inflammatory response modulation
• osteoporosis